THE SMART TRICK OF TRASTUZUMAB DRUG CLASS THAT NO ONE IS DISCUSSING

The phosphorylated HER3 provides docking websites for p85 subunit of PI3K. The completely activated PI3K complex is created by binding of p110 subunit of PI3K to p85 which will be able to produce PIP3 via phosphorylating the PIP2. AKT binds to PIP3 which is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both of those threonine and ser